Domain organisation in phosphomannose isomerases (types I and II)
SO Jensen, PR Reeves - Biochimica et Biophysica Acta (BBA)-Protein …, 1998 - Elsevier
Phosphomannose isomerase (PMI) types I and II were found to possess a conserved protein
motif. This motif coincides with the catalytic site of the Candida albicans type I PMI, indicating
a common catalytic process for both PMI types. The type II PMI are bifunctional enzymes
possessing PMI and guanosine diphospho-d-mannose pyrophosphorylase (GMP) activity in
separate catalytic domains, which in some species may function as separate proteins.
motif. This motif coincides with the catalytic site of the Candida albicans type I PMI, indicating
a common catalytic process for both PMI types. The type II PMI are bifunctional enzymes
possessing PMI and guanosine diphospho-d-mannose pyrophosphorylase (GMP) activity in
separate catalytic domains, which in some species may function as separate proteins.