[HTML][HTML] Crystal structure of Escherichia coli glucose-1-phosphate thymidylyltransferase (RffH) complexed with dTTP and Mg2+
J Sivaraman, V Sauvé, A Matte, M Cygler - Journal of Biological Chemistry, 2002 - ASBMB
The enzyme glucose-1-phosphate thymidylyltransferase (RffH), the product of therffh gene,
catalyzes one of the steps in the synthesis of enterobacterial common antigen (ECA), a cell
surface glycolipid found in Gram-negative enteric bacteria. InEscherichia coli two gene
products, RffH and RmlA, catalyze the same enzymatic reaction and are homologous in
sequence; however, they are part of different operons and function in different pathways. We
report the crystal structure of RffH bound to deoxythymidine triphosphate (dTTP), the …
catalyzes one of the steps in the synthesis of enterobacterial common antigen (ECA), a cell
surface glycolipid found in Gram-negative enteric bacteria. InEscherichia coli two gene
products, RffH and RmlA, catalyze the same enzymatic reaction and are homologous in
sequence; however, they are part of different operons and function in different pathways. We
report the crystal structure of RffH bound to deoxythymidine triphosphate (dTTP), the …