Isometric and eccentric force generation assessment of skeletal muscles isolated from murine models of muscular dystrophies
C Moorwood, M Liu, Z Tian, ER Barton - JoVE (Journal of Visualized …, 2013 - jove.com
Critical to the evaluation of potential therapeutics for muscular disease are sensitive and
reproducible physiological assessments of muscle function. Because many pre-clinical trials
rely on mouse models for these diseases, isolated muscle function has become one of the
standards for Go/NoGo decisions in moving drug candidates forward into patients. We will
demonstrate the preparation of the extensor digitorum longus (EDL) and diaphragm muscles
for functional testing, which are the predominant muscles utilized for these studies. The EDL …
reproducible physiological assessments of muscle function. Because many pre-clinical trials
rely on mouse models for these diseases, isolated muscle function has become one of the
standards for Go/NoGo decisions in moving drug candidates forward into patients. We will
demonstrate the preparation of the extensor digitorum longus (EDL) and diaphragm muscles
for functional testing, which are the predominant muscles utilized for these studies. The EDL …