[HTML][HTML] A high-cholesterol diet increases the association between caveolae and insulin receptors in rat liver
M Hahn-Obercyger, L Graeve, Z Madar - Journal of lipid research, 2009 - ASBMB
Caveolin-1, a component of caveolae, regulates signaling pathway compartmentalization by
interacting with tyrosine (Tyr) kinase receptors and their substrates. Perturbations in
caveolae lipid composition have been shown in vitro to displace proteins from lipid
microdomains, thereby altering their functionality and subsequent downstream signaling.
The role of caveolin-1 in insulin receptor (IR) signaling has been widely investigated in vitro
mainly in 3T3-L1 adipocyte cells. However, in vivo experiments investigating this connection …
interacting with tyrosine (Tyr) kinase receptors and their substrates. Perturbations in
caveolae lipid composition have been shown in vitro to displace proteins from lipid
microdomains, thereby altering their functionality and subsequent downstream signaling.
The role of caveolin-1 in insulin receptor (IR) signaling has been widely investigated in vitro
mainly in 3T3-L1 adipocyte cells. However, in vivo experiments investigating this connection …