[HTML][HTML] Transforming growth factor-β family ligands can function as antagonists by competing for type II receptor binding
S Aykul, E Martinez-Hackert - Journal of Biological Chemistry, 2016 - ASBMB
Transforming growth factor-β (TGF-β) family ligands are pleiotropic cytokines. Their
physiological activities are not determined by a simple coupling of stimulus and response,
but depend critically on context, ie the interplay of receptors, ligands, and regulators that
form the TGF-β signal transduction system of a cell or tissue. How these different
components combine to regulate signaling activities remains poorly understood. Here, we
describe a ligand-mediated mechanism of signaling regulation. Based on the observation …
physiological activities are not determined by a simple coupling of stimulus and response,
but depend critically on context, ie the interplay of receptors, ligands, and regulators that
form the TGF-β signal transduction system of a cell or tissue. How these different
components combine to regulate signaling activities remains poorly understood. Here, we
describe a ligand-mediated mechanism of signaling regulation. Based on the observation …