Mechanisms of cachexia in chronic disease states
T Yoshida, P Delafontaine - The American journal of the medical sciences, 2015 - Elsevier
Sarcopenia and cachexia are muscle wasting syndromes associated with aging and with
many chronic diseases, such as congestive heart failure (CHF), diabetes, cancer, chronic
obstructive pulmonary disease and chronic kidney disease (CKD). While mechanisms are
complex, these conditions are often accompanied by elevated angiotensin II (Ang II).
Patients with advanced CHF or CKD often have increased Ang II levels and cachexia, and
angiotensin-converting enzyme inhibitor treatment improves weight loss. It was found that …
many chronic diseases, such as congestive heart failure (CHF), diabetes, cancer, chronic
obstructive pulmonary disease and chronic kidney disease (CKD). While mechanisms are
complex, these conditions are often accompanied by elevated angiotensin II (Ang II).
Patients with advanced CHF or CKD often have increased Ang II levels and cachexia, and
angiotensin-converting enzyme inhibitor treatment improves weight loss. It was found that …