Imatinib attenuates severe mouse dystrophy and inhibits proliferation and fibrosis-marker expression in muscle mesenchymal progenitors
T Ito, R Ogawa, A Uezumi, T Ohtani, Y Watanabe… - Neuromuscular …, 2013 - Elsevier
Imatinib mesylate inhibits signaling of tyrosine kinase receptors, including PDGFRα, and has
been used for human cancer therapy. Recent studies have indicated that imatinib is also
effective in treatment of some chronic diseases with fibrosis. Fibrosis is the feature of
Duchenne muscular dystrophy. It has been reported that imatinib attenuates fibrosis in mdx
mice. Recently we revealed that PDGFRα is specifically expressed in muscle mesenchymal
progenitors, which are the origin of muscle fibrosis. Here, we show that imatinib ameliorates …
been used for human cancer therapy. Recent studies have indicated that imatinib is also
effective in treatment of some chronic diseases with fibrosis. Fibrosis is the feature of
Duchenne muscular dystrophy. It has been reported that imatinib attenuates fibrosis in mdx
mice. Recently we revealed that PDGFRα is specifically expressed in muscle mesenchymal
progenitors, which are the origin of muscle fibrosis. Here, we show that imatinib ameliorates …