[HTML][HTML] Role of phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) 5-phosphatase skeletal muscle-and kidney-enriched inositol polyphosphate phosphatase (SKIP) in …
T Ijuin, T Takenawa - Journal of Biological Chemistry, 2012 - ASBMB
Insulin-like growth factors (IGFs) are essential for the development, regeneration, and
hypertrophy of skeletal muscles. IGF-II promotes myoblast differentiation through
phosphatidylinositol 3-kinase (PI 3-kinase), Akt, and mTOR signaling. Here, we report that
skeletal muscle-and kidney-enriched inositol polyphosphate phosphatase (SKIP) negatively
regulates myogenesis through inhibition of IGF-II production and attenuation of the IGF-II-Akt-
mTOR signaling pathway. We also demonstrate that SKIP expression, which was markedly …
hypertrophy of skeletal muscles. IGF-II promotes myoblast differentiation through
phosphatidylinositol 3-kinase (PI 3-kinase), Akt, and mTOR signaling. Here, we report that
skeletal muscle-and kidney-enriched inositol polyphosphate phosphatase (SKIP) negatively
regulates myogenesis through inhibition of IGF-II production and attenuation of the IGF-II-Akt-
mTOR signaling pathway. We also demonstrate that SKIP expression, which was markedly …