[HTML][HTML] Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) phosphatase, skeletal …
T Ijuin, T Takenawa - Journal of Biological Chemistry, 2012 - ASBMB
The glucose transporter 4 (GLUT4) is responsible for glucose uptake in the skeletal muscle.
Insulin-induced translocation of GLUT4 to the plasma membrane requires
phosphatidylinositol 3-kinase activation-mediated generation of phosphatidylinositol 3, 4, 5-
trisphosphate PIP 3 and subsequent activation of Akt. Previous studies suggested that
skeletal muscle and kidney enriched inositol polyphosphate phosphatase (SKIP) has
negative effects on the regulation of insulin signaling in the skeletal muscle cells. Here, we …
Insulin-induced translocation of GLUT4 to the plasma membrane requires
phosphatidylinositol 3-kinase activation-mediated generation of phosphatidylinositol 3, 4, 5-
trisphosphate PIP 3 and subsequent activation of Akt. Previous studies suggested that
skeletal muscle and kidney enriched inositol polyphosphate phosphatase (SKIP) has
negative effects on the regulation of insulin signaling in the skeletal muscle cells. Here, we …