[HTML][HTML] Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle
X Liang, L Liu, T Fu, Q Zhou, D Zhou, L Xiao… - Journal of Biological …, 2016 - ASBMB
Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate, which
are critical fuel metabolites of skeletal muscle particularly during exercise. However, the
physiological relevance of LDH remains poorly understood. Here we show that Ldhb
expression is induced by exercise in human muscle and negatively correlated with changes
in intramuscular pH levels, a marker of lactate production, during isometric exercise. We
found that the expression of Ldhb is regulated by exercise-induced peroxisome proliferator …
are critical fuel metabolites of skeletal muscle particularly during exercise. However, the
physiological relevance of LDH remains poorly understood. Here we show that Ldhb
expression is induced by exercise in human muscle and negatively correlated with changes
in intramuscular pH levels, a marker of lactate production, during isometric exercise. We
found that the expression of Ldhb is regulated by exercise-induced peroxisome proliferator …