[HTML][HTML] Inhibitors and chemical probes for molecular chaperone networks
JE Gestwicki, H Shao - Journal of Biological Chemistry, 2019 - ASBMB
The molecular chaperones are central mediators of protein homeostasis. In that role, they
engage in widespread protein–protein interactions (PPIs) with each other and with their"
client" proteins. Together, these PPIs form the backbone of a network that ensures proper
vigilance over the processes of protein folding, trafficking, quality control, and degradation.
The core chaperones, such as the heat shock proteins Hsp60, Hsp70, and Hsp90, are
widely expressed in most tissues, yet there is growing evidence that the PPIs among them …
engage in widespread protein–protein interactions (PPIs) with each other and with their"
client" proteins. Together, these PPIs form the backbone of a network that ensures proper
vigilance over the processes of protein folding, trafficking, quality control, and degradation.
The core chaperones, such as the heat shock proteins Hsp60, Hsp70, and Hsp90, are
widely expressed in most tissues, yet there is growing evidence that the PPIs among them …