[HTML][HTML] Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma …
Microsomal triglyceride transfer protein (MTP) is a target to reduce plasma lipids because of
its indispensable role in triglyceride-rich lipoprotein biosynthesis. MTP inhibition in Western
diet fed mice decreased plasma triglycerides/cholesterol, whereas increasing plasma
alanine/aspartate aminotransferases (ALT/AST) and hepatic triglycerides/free cholesterol.
Free cholesterol accumulated in the endoplasmic reticulum (ER) and mitochondria resulting
in ER and oxidative stresses. Mechanistic studies revealed that MTP inhibition increased …
its indispensable role in triglyceride-rich lipoprotein biosynthesis. MTP inhibition in Western
diet fed mice decreased plasma triglycerides/cholesterol, whereas increasing plasma
alanine/aspartate aminotransferases (ALT/AST) and hepatic triglycerides/free cholesterol.
Free cholesterol accumulated in the endoplasmic reticulum (ER) and mitochondria resulting
in ER and oxidative stresses. Mechanistic studies revealed that MTP inhibition increased …
