Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation …

GD Slade, MS Conrad, L Diatchenko, NU Rashid… - Pain, 2011 - Elsevier
For reasons unknown, temporomandibular disorder (TMD) can manifest as localized pain or
in conjunction with widespread pain. We evaluated relationships between cytokines and
TMD without or with widespread palpation tenderness (TMD− WPT or TMD+ WPT,
respectively) at protein, transcription factory activity, and gene levels. Additionally, we
evaluated the relationship between cytokines and intermediate phenotypes characteristic of
TMD and WPT. In a case-control study of 344 females, blood samples were analyzed for …