[HTML][HTML] Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism

R Karuna, AG Holleboom, MM Motazacker… - Atherosclerosis, 2011 - Elsevier
Secretion of 27-hydroxycholesterol (27OHC) from macrophages is considered as an
alternative to HDL-mediated reverse transport of excess cholesterol. We investigated
27OHC-concentrations in plasma of humans and mice with monogenic disorders of HDL
metabolism. As compared to family controls mutations in the genes for apolipoprotein AI,
ATP binding cassette transporter (ABC) A1 and lecithin: cholesterol acylstransferase (LCAT)
were associated with reduced concentrations of both HDL-cholesterol and HDL-27OHC …