[HTML][HTML] A Role for Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1) in the Regulation of Cardiac Mitochondrial Phospholipid Biosynthesis*♦
L Lai, M Wang, OJ Martin, TC Leone, RB Vega… - Journal of Biological …, 2014 - ASBMB
The energy demands of the adult mammalian heart are met largely by ATP generated via
oxidation of fatty acids in a high capacity mitochondrial system. Peroxisome proliferator-
activated receptor γ coactivator 1 (PGC-1)-α and-β serve as inducible transcriptional
coregulators of genes involved in mitochondrial biogenesis and metabolism. Whether PGC-
1 plays a role in the regulation of mitochondrial structure is unknown. In this study, mice with
combined deficiency of PGC-1α and PGC-1β (PGC-1αβ−/−) in adult heart were analyzed …
oxidation of fatty acids in a high capacity mitochondrial system. Peroxisome proliferator-
activated receptor γ coactivator 1 (PGC-1)-α and-β serve as inducible transcriptional
coregulators of genes involved in mitochondrial biogenesis and metabolism. Whether PGC-
1 plays a role in the regulation of mitochondrial structure is unknown. In this study, mice with
combined deficiency of PGC-1α and PGC-1β (PGC-1αβ−/−) in adult heart were analyzed …