High Frequency of p53 Mutations in Ultraviolet Radiation-induced Murine Skin Tumors: Evidence for Strand Bias and Tumor Heterogeneity
S Kanjilal, WE Pierceall, KK Cummings, ML Kripke… - Cancer research, 1993 - AACR
S Kanjilal, WE Pierceall, KK Cummings, ML Kripke, HN Ananthaswamy
Cancer research, 1993•AACRExposure to UV radiation has long been associated with the development of skin cancers.
To identify the molecular targets in UV carcinogenesis, we analyzed 11 UV-induced murine
skin cancers for mutations in the p53 tumor suppressor gene and found a 100% incidence
rate. Such a high frequency of p53 mutations is unprecedented and suggests that this gene
plays an important role in the development of UV-induced skin cancers. The mutations were
predominantly “UV-signature” transitions (C→ T and CC→ TT) at pyrimidine-rich sequences …
To identify the molecular targets in UV carcinogenesis, we analyzed 11 UV-induced murine
skin cancers for mutations in the p53 tumor suppressor gene and found a 100% incidence
rate. Such a high frequency of p53 mutations is unprecedented and suggests that this gene
plays an important role in the development of UV-induced skin cancers. The mutations were
predominantly “UV-signature” transitions (C→ T and CC→ TT) at pyrimidine-rich sequences …
Abstract
Exposure to UV radiation has long been associated with the development of skin cancers. To identify the molecular targets in UV carcinogenesis, we analyzed 11 UV-induced murine skin cancers for mutations in the p53 tumor suppressor gene and found a 100% incidence rate. Such a high frequency of p53 mutations is unprecedented and suggests that this gene plays an important role in the development of UV-induced skin cancers. The mutations were predominantly “UV-signature” transitions (C→T and CC→TT) at pyrimidine-rich sequences located on the nontranscribed strand of the gene. In addition, seven tumors harbored multiple mutant alleles of p53, providing strong evidence for tumor heterogeneity at the molecular level.
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