Caloric intake and aging
R Weindruch, RS Sohal - New England Journal of Medicine, 1997 - Mass Medical Soc
R Weindruch, RS Sohal
New England Journal of Medicine, 1997•Mass Medical SocIn postindustrial societies, overeating, inactivity, and obesity have emerged as new
challenges in public health. 1, 2 Considerable effort is now being devoted to determining the
pathophysiologic consequences of overeating. Several lines of evidence suggest that
caloric intake influences the rate of aging and the onset of associated diseases in animals
and, possibly, humans. 3–5 The observation that laboratory rats not only live longer but also
have fewer age-associated diseases when their food intake is restricted dates back to the …
challenges in public health. 1, 2 Considerable effort is now being devoted to determining the
pathophysiologic consequences of overeating. Several lines of evidence suggest that
caloric intake influences the rate of aging and the onset of associated diseases in animals
and, possibly, humans. 3–5 The observation that laboratory rats not only live longer but also
have fewer age-associated diseases when their food intake is restricted dates back to the …
In postindustrial societies, overeating, inactivity, and obesity have emerged as new challenges in public health.1,2 Considerable effort is now being devoted to determining the pathophysiologic consequences of overeating. Several lines of evidence suggest that caloric intake influences the rate of aging and the onset of associated diseases in animals and, possibly, humans.3–5
The observation that laboratory rats not only live longer but also have fewer age-associated diseases when their food intake is restricted dates back to the 1930s.3–7 Numerous subsequent studies have found that when the ad libitum food intake of mice and rats was reduced by . . .
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