Regulation of cytochrome P450 genes: molecular mechanisms
FJ Gonzalez, SY Liu, M Yano - Pharmacogenetics and Genomics, 1993 - journals.lww.com
The xenobiotic-metabolizing cytochrome P450s are found in the CYP1, CYP2, CYP3 and
CYP4 subfamilies (Gonzalez, 1988). These P450s have been extensively studied in a
number of organisms including bacteria, yeast, fish, chickens, rats, mice, rabbits and
humans. The P450 genes are under control of diverse regulatory networks that govern their
expression. These networks include foreign chemical receptors that activate gene
expression through binding to inducible enhancer elements and tissue-enriched …
CYP4 subfamilies (Gonzalez, 1988). These P450s have been extensively studied in a
number of organisms including bacteria, yeast, fish, chickens, rats, mice, rabbits and
humans. The P450 genes are under control of diverse regulatory networks that govern their
expression. These networks include foreign chemical receptors that activate gene
expression through binding to inducible enhancer elements and tissue-enriched …