Proteolysis of macrophage inflammatory protein-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases
OH Ryu, SJ Choi, E Firatli, SW Choi, PS Hart… - Journal of Biological …, 2005 - ASBMB
Macrophage inflammatory protein-1α (MIP-1α) is a chemokine that leads to leukocyte
recruitment and activation at sites of infection. Controlling chemokine activity at sites of
infection is important, since excess accumulation of leukocytes may contribute to localized
tissue damage. Neutrophil-derived serine proteases modulate the bioactivity of chemokine
and cytokine networks through proteolytic cleavage. Because MIP-1α is temporally
expressed with neutrophils at sites of infection, we examined proteolysis of MIP-1α in vitro by …
recruitment and activation at sites of infection. Controlling chemokine activity at sites of
infection is important, since excess accumulation of leukocytes may contribute to localized
tissue damage. Neutrophil-derived serine proteases modulate the bioactivity of chemokine
and cytokine networks through proteolytic cleavage. Because MIP-1α is temporally
expressed with neutrophils at sites of infection, we examined proteolysis of MIP-1α in vitro by …
