[HTML][HTML] Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis
S Kanaji, SA Fahs, Q Shi, SL Haberichter… - Journal of Thrombosis …, 2012 - Elsevier
Background: von Willebrand factor (VWF) is a glycoprotein that plays an important role in
primary hemostasis. VWF is synthesized and stored in endothelial cells (ECs) and
megakaryocytes/platelets. Plasma VWF is primarily derived from ECs and is generally
believed to be essential for hemostasis. VWF synthesized in megakaryocytes is stored in
platelet α‐granules, from which it is released following platelet activation. The relative
contribution of VWF stored in ECs or megakaryocytes/platelets or present in plasma to …
primary hemostasis. VWF is synthesized and stored in endothelial cells (ECs) and
megakaryocytes/platelets. Plasma VWF is primarily derived from ECs and is generally
believed to be essential for hemostasis. VWF synthesized in megakaryocytes is stored in
platelet α‐granules, from which it is released following platelet activation. The relative
contribution of VWF stored in ECs or megakaryocytes/platelets or present in plasma to …