[HTML][HTML] Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation
AL Williams, N Bielopolski, D Meroz, AD Lam… - Journal of Biological …, 2011 - ASBMB
Tomosyn is a 130-kDa cytosolic R-SNARE protein that associates with Q-SNAREs and
reduces exocytotic activity. Two paralogous genes, tomosyn-1 and-2, occur in mammals and
produce seven different isoforms via alternative splicing. Here, we map the structural
differences between the yeast homologue of m-tomosyn-1, Sro7, and tomosyn
genes/isoforms to identify domains critical to the regulation of exocytotic activity to tomosyn
that are outside the soluble N-ethylmaleimide-sensitive attachment receptor motif. Homology …
reduces exocytotic activity. Two paralogous genes, tomosyn-1 and-2, occur in mammals and
produce seven different isoforms via alternative splicing. Here, we map the structural
differences between the yeast homologue of m-tomosyn-1, Sro7, and tomosyn
genes/isoforms to identify domains critical to the regulation of exocytotic activity to tomosyn
that are outside the soluble N-ethylmaleimide-sensitive attachment receptor motif. Homology …