Mechanisms of intracellular protein transport
JE Rothman - Nature, 1994 - nature.com
Nature, 1994•nature.com
Recent advances have uncovered the general protein apparatus used by all eukaryotes for
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of
hormones and neurotransmitters. Membranes are shaped into vesicles by cytoplasmic coats
which then dissociate upon GTP hydrolysis. Both vesicles and their acceptor membranes
carry targeting proteins which interact specifically to initiate docking. A general apparatus
then assembles at the docking site and fuses the vesicle with its target.
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of
hormones and neurotransmitters. Membranes are shaped into vesicles by cytoplasmic coats
which then dissociate upon GTP hydrolysis. Both vesicles and their acceptor membranes
carry targeting proteins which interact specifically to initiate docking. A general apparatus
then assembles at the docking site and fuses the vesicle with its target.
Abstract
Recent advances have uncovered the general protein apparatus used by all eukaryotes for intracellular transport, including secretion and endocytosis, and for triggered exocytosis of hormones and neurotransmitters. Membranes are shaped into vesicles by cytoplasmic coats which then dissociate upon GTP hydrolysis. Both vesicles and their acceptor membranes carry targeting proteins which interact specifically to initiate docking. A general apparatus then assembles at the docking site and fuses the vesicle with its target.
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