Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl) uracil that increases the level and toxicity of 5 …
H Nakayama, T Kinouchi, K Kataoka… - Pharmacogenetics …, 1997 - journals.lww.com
Abstract Sorivudine, l-[beta]-D-arabinofuranosyl-5-(E)-(2-bromovinyl) uracil, is a potent
antiviral agent against varicella-zoster virus and herpes simplex virus type 1. However,
sorivudine should not be used in combination with anticancer drugs such as 5-fluorouracil (5-
FU) because (E)-5-(2-bromovinyI) uracil (BVU), a metabolite of sorivudine, inhibits the
degradation of 5-FU, resulting in its accumulation in the blood and marked enhancement of
the toxicity of 5-FU. Since phosphorolytic enzymes generate BVU from sorivudine, we …
antiviral agent against varicella-zoster virus and herpes simplex virus type 1. However,
sorivudine should not be used in combination with anticancer drugs such as 5-fluorouracil (5-
FU) because (E)-5-(2-bromovinyI) uracil (BVU), a metabolite of sorivudine, inhibits the
degradation of 5-FU, resulting in its accumulation in the blood and marked enhancement of
the toxicity of 5-FU. Since phosphorolytic enzymes generate BVU from sorivudine, we …