Disturbance of real space navigation in moderately advanced but not in early Huntington's disease
V Majerová, T Kalinčík, J Laczó, M Vyhnálek… - Journal of the …, 2012 - Elsevier
BACKGROUND: Visuospatial skills including spatial navigation are known to be impaired in
Huntington's disease. Spatial navigation comprises two navigational frameworks, allocentric
and egocentric. Several studies have associated the allocentric navigation with the
hippocampus and the egocentric navigation with the striatum. The striatum is predominantly
impaired from the early stages of Huntington's disease. OBJECTIVE: To find whether spatial
navigation impairment is present in the early stages of Huntington's disease and to test the …
Huntington's disease. Spatial navigation comprises two navigational frameworks, allocentric
and egocentric. Several studies have associated the allocentric navigation with the
hippocampus and the egocentric navigation with the striatum. The striatum is predominantly
impaired from the early stages of Huntington's disease. OBJECTIVE: To find whether spatial
navigation impairment is present in the early stages of Huntington's disease and to test the …