Efficient purification and reconstitution of ATP binding cassette transporter B6 (ABCB6) for functional and structural studies
H Chavan, MMT Khan, G Tegos… - Journal of Biological …, 2013 - ASBMB
The mitochondrial ATP binding cassette transporter ABCB6 has been associated with a
broad range of physiological functions, including growth and development, therapy-related
drug resistance, and the new blood group system Langereis. ABCB6 has been proposed to
regulate heme synthesis by shuttling coproporphyrinogen III from the cytoplasm into the
mitochondria. However, direct functional information of the transport complex is not known.
To understand the role of ABCB6 in mitochondrial transport, we developed an in vitro system …
broad range of physiological functions, including growth and development, therapy-related
drug resistance, and the new blood group system Langereis. ABCB6 has been proposed to
regulate heme synthesis by shuttling coproporphyrinogen III from the cytoplasm into the
mitochondria. However, direct functional information of the transport complex is not known.
To understand the role of ABCB6 in mitochondrial transport, we developed an in vitro system …
