[HTML][HTML] Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network
AM Kong, CJ Speed, CJ O'Malley, MJ Layton… - Journal of Biological …, 2000 - ASBMB
The inositol-polyphosphate 5-phosphatase enzyme family removes the 5-position
phosphate from both inositol phosphate and phosphoinositide signaling molecules. We
have cloned and characterized a novel 5-phosphatase, which demonstrates a restricted
substrate specificity and tissue expression. The 3.9-kb cDNA predicts for a 72-kDa protein
with an N-terminal proline rich domain, a central 5-phosphatase domain, and a C-terminal
CAAX motif. The 3.9-kilobase mRNA showed a restricted expression but was abundant in …
phosphate from both inositol phosphate and phosphoinositide signaling molecules. We
have cloned and characterized a novel 5-phosphatase, which demonstrates a restricted
substrate specificity and tissue expression. The 3.9-kb cDNA predicts for a 72-kDa protein
with an N-terminal proline rich domain, a central 5-phosphatase domain, and a C-terminal
CAAX motif. The 3.9-kilobase mRNA showed a restricted expression but was abundant in …
