[HTML][HTML] Hypertonic stress activates glycogen synthase kinase 3β-mediated apoptosis of renal medullary interstitial cells, suppressing an NFκB-driven cyclooxygenase …
The survival of renal medullary interstitial cells (RMICs) requires their adaptation to rapid
shifts in ambient tonicity normally occurring in the renal medulla. Previous studies
determined that cyclooxygenase-2 (COX 2) activation is critical for this adaptation. The
present studies find that these adaptive mechanisms are dampened by the simultaneous
activation of an apoptotic pathway linked to a glycogen synthase kinase 3β (GSK 3β).
Inhibition of GSK 3 by LiCl or specific small molecule GSK inhibitors increased RMIC …
shifts in ambient tonicity normally occurring in the renal medulla. Previous studies
determined that cyclooxygenase-2 (COX 2) activation is critical for this adaptation. The
present studies find that these adaptive mechanisms are dampened by the simultaneous
activation of an apoptotic pathway linked to a glycogen synthase kinase 3β (GSK 3β).
Inhibition of GSK 3 by LiCl or specific small molecule GSK inhibitors increased RMIC …
