PURPOSE: Hypoxia renders tumor cells radioresistant, limiting locoregional control from
radiotherapy (RT). Intensity-modulated RT (IMRT) allows for targeting of the gross tumor
volume (GTV) and can potentially deliver a greater dose to hypoxic subvolumes (GTVh)
while sparing normal tissues. A Monte Carlo model has shown that boosting the GTVh
increases the tumor control probability. This study examined the feasibility of fluorine-18–
labeled fluoromisonidazole positron emission tomography/computed tomography (18F …