Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4
M Mari, E Macia, Y Le Marchand-Brustel… - Journal of Biological …, 2001 - ASBMB
Rabip4 is a Rab4 effector, which possesses a RUN domain, two coiled-coil domains, and a
FYVE finger. It is associated with the early endosomes and leads, in concert with Rab4, to
the enlargement of endosomes, resulting in the fusion of sorting and recycling endosomes.
Our goal was to characterize the role of these various domains in Rabip4 subcellular
localization and their function in Chinese hamster ovary cells. Although the FYVE finger
domain specifically bound phosphatidylinositol 3-phosphate and was necessary for the …
FYVE finger. It is associated with the early endosomes and leads, in concert with Rab4, to
the enlargement of endosomes, resulting in the fusion of sorting and recycling endosomes.
Our goal was to characterize the role of these various domains in Rabip4 subcellular
localization and their function in Chinese hamster ovary cells. Although the FYVE finger
domain specifically bound phosphatidylinositol 3-phosphate and was necessary for the …
