Antigen‐induced arthritis in mice
D Brackertz, GF Mitchell, IR Mackay - Arthritis & Rheumatism, 1977 - Wiley Online Library
D Brackertz, GF Mitchell, IR Mackay
Arthritis & Rheumatism, 1977•Wiley Online LibraryAntigen‐induced arthritis was established in the mouse by immunization with methylated
bovine serum albumin (mBSA) in complete Freund's adjuvant with B pertussis vaccine. The
knee joint was injected after 21 days with mBSA in saline. The arthritis was chronic, antigen‐
specific, and T‐cell dependent in hypothymic nu/nu mice. C57BL and BALB/c mice were
susceptible, whereas CBA mice were relatively resistant. Susceptibility was dominant; one
gene was loosely linked to the “b” allele of the H‐2 complex of C57BL mice.
bovine serum albumin (mBSA) in complete Freund's adjuvant with B pertussis vaccine. The
knee joint was injected after 21 days with mBSA in saline. The arthritis was chronic, antigen‐
specific, and T‐cell dependent in hypothymic nu/nu mice. C57BL and BALB/c mice were
susceptible, whereas CBA mice were relatively resistant. Susceptibility was dominant; one
gene was loosely linked to the “b” allele of the H‐2 complex of C57BL mice.
Abstract
Antigen‐induced arthritis was established in the mouse by immunization with methylated bovine serum albumin (mBSA) in complete Freund's adjuvant with B pertussis vaccine. The knee joint was injected after 21 days with mBSA in saline. The arthritis was chronic, antigen‐specific, and T‐cell dependent in hypothymic nu/nu mice. C57BL and BALB/c mice were susceptible, whereas CBA mice were relatively resistant. Susceptibility was dominant; one gene was loosely linked to the “b” allele of the H‐2 complex of C57BL mice.
Wiley Online Library