Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1
TBH Geijtenbeek, GCF van Duijnhoven… - Journal of Biological …, 2002 - ASBMB
The novel dendritic cell (DC)-specific human immunodeficiency virus type 1 (HIV-1) receptor
DC-SIGN plays a key role in the dissemination of HIV-1 by DC. DC-SIGN is thought to
capture HIV-1 at mucosal sites of entry, facilitating transport to lymphoid tissues, where DC-
SIGN efficiently transmits HIV-1 to T cells. DC-SIGN is also important in the initiation of
immune responses by regulating DC-T cell interactions through intercellular adhesion
molecule 3 (ICAM-3). We have characterized the mechanism of ligand binding by DC-SIGN …
DC-SIGN plays a key role in the dissemination of HIV-1 by DC. DC-SIGN is thought to
capture HIV-1 at mucosal sites of entry, facilitating transport to lymphoid tissues, where DC-
SIGN efficiently transmits HIV-1 to T cells. DC-SIGN is also important in the initiation of
immune responses by regulating DC-T cell interactions through intercellular adhesion
molecule 3 (ICAM-3). We have characterized the mechanism of ligand binding by DC-SIGN …
