[HTML][HTML] An internalization signal in ClC-5, an endosomal Cl− channel mutated in Dent's disease
M Schwake, T Friedrich, TJ Jentsch - Journal of Biological Chemistry, 2001 - ASBMB
The ClC-5 chloride channel resides mainly in vesicles of the endocytotic pathway and
contributes to their acidification. Its disruption in mice entails a broad defect in renal
endocytosis and causes secondary changes in calciotropic hormone levels. Inactivating
mutations in Dent's disease lead to proteinuria and kidney stones. Possibly by recycling, a
small fraction of ClC-5 also reaches the plasma membrane. Here we identify a carboxyl-
terminal internalization motif in ClC-5. It resembles the PY motif, which is crucial for the …
contributes to their acidification. Its disruption in mice entails a broad defect in renal
endocytosis and causes secondary changes in calciotropic hormone levels. Inactivating
mutations in Dent's disease lead to proteinuria and kidney stones. Possibly by recycling, a
small fraction of ClC-5 also reaches the plasma membrane. Here we identify a carboxyl-
terminal internalization motif in ClC-5. It resembles the PY motif, which is crucial for the …
