Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection
K Winzer, Y Sun, A Green, M Delory… - Infection and …, 2002 - Am Soc Microbiol
Infection and immunity, 2002•Am Soc Microbiol
Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production.
Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is
necessary for full meningococcal virulence; strains with a luxS deletion are defective for
bacteremia, a prerequisite of meningococcal pathogenesis.
Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is
necessary for full meningococcal virulence; strains with a luxS deletion are defective for
bacteremia, a prerequisite of meningococcal pathogenesis.
Abstract
Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.
American Society for Microbiology